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A MOTHERLY MESH
SIB Protein Spotlight -  issue May 2024
www.proteinspotlight.org

Most mammalian oocytes are arrested at a certain developmental stage as they await ovulation - which may take several decades. During this rather long period, oocytes are kept in a sort of lethargic state and are unable to deal with degradation. So how do they cope with their waste? The answer is ELVAs, or endo-lysosomal vesicular assemblies. Much like fishnets, ELVAs trap noxious scrap within a proteinaceous mesh whose formation is initiated by a protein known as RUFY1.
Jessica Dismorr (1885-1939)